FedEx was founded by former US Marine Corps member Frederick W. Smith in Little Rock, Arkansas in 1971, but moved to Memphis, Tennessee in 1973 because officials at Little Rock airport refused to provide facilities for the company.

After relocating to Tennessee, FedEx provided services to 25 cities, but faced numerous difficulties and suffered significant losses in the early stages. But a few years later, the business began to improve, and in July 1975, the company made its first profit. In 1978, FedEx was officially launched.

At present, FedEx serves 3 million customers in 210 cities every day. Its main competitors include DHL, UPS, and USPS. The $96 million venture capital incubation of FedEx has also set a record for the highest single investment in the history of the United States.

If FedEx had failed, people would not have seen the unprecedented prosperity of today's venture capital market. Although the venture capital market would still exist, its level of activity would be much lower.

FedEx was one of the earliest foreign companies to recognize the huge market in China. It entered China in 1984 and has developed rapidly in the past 20 years, achieving remarkable results year by year and setting many world records. The company, which used to operate twice a week, now has 11 flights in and out of China every week, making it the international courier company with the most direct flights to China; In 1996, there were only 60 cities providing express delivery services, but now it has grown to 220 cities; In 1999, FedEx and Tianjin Datian Group established a joint venture, Datian FedEx Co., Ltd., in Beijing. The cooperation between the two parties was smooth and close, further promoting the development of China's express delivery business. The first phase of the FedEx Asia Pacific Transit Center project started construction on January 16th in Huadong Town, Huadu District, Guangzhou. The Asia Pacific Transit Center was put into operation in October 2008. FedEx was the first multinational freight giant to establish an intercontinental transit center in China, bringing $150 million in investment, an annual cargo volume of 600000 tons, and the opportunity for Baiyun Airport to take off.